To examine the pathological differences of Aβ deposition in parenchyma and those related to the vasculature, Hondius and colleagues performed a discovery proteomics analysis on laser capture microdissected tissues of the occipital tissues from six cases of healthy controls without any Aβ or tau pathologies, seven cases of AD with severe plaque pathology but no vascular deposits, and seven cases of AD with severe CAA‐type 1 pathology and a negligible amount of plaque pathology (Hondius et al. This evidence concerns the gene MAPT and Alzheimer disease.