2016). More than 1900 proteins were identified in total, of which 56 proteins were considered differentially regulated between groups. ELISA assays were performed on a small set of these proteins, namely FABP4, YKL‐40, complement factor D, IL1RAP and APOL1, where only YKL‐40 could be validated to exhibit higher levels in FTD cases than controls. YKL‐40 has been found to be increased in different neurodegenerative diseases (Alcolea et al. 2014), and may reflect the abnormality of astrocyte activity associated with inflammatory processes (Llorens et al. 2017). Here, CHI3L1 is linked to neurodegenerative disease.