In this study we sought to (i) validate the association of rs10846744 with SCA and CV events from consortium-based GWAS, (ii) examine associations of rs10846744 with Lp-PLA2 mass and activity, inflammatory markers and fatty acids in MESA, and (iii) perform formal mediation analyses to quantify the role of selected covariates as mediators of the association of rs10846744 with cIMT in MESA. This evidence concerns the gene PLA2G7 and autosomal dominant cerebellar ataxia.