ACHE and Alzheimer disease: The inhibition potency of those compounds was up to 1000 times lower compared to compounds in the use as anti-AD drugs; galantamine (IC50 = 0.8 μM in human AChE), huperzine A (IC50 = 0.047 μM in human AChE) and donepezil (IC50 = 0.038 nM in hAChE) [2, 15, 43].