Finally, this study did not detect association with other loci previously associated with endocarditis (SLC7A14 [38], in a study that included a subset of the Danish sample used here in the non-significant replication), with risk of SAB (HLA class II region [6]), or with biologically plausible candidate genes identified from prior human and mouse studies (DUSP3, FGA, FGB, FGG, FN1, PSME3, SPINK5, TNFAIP8). This evidence concerns the gene SPINK5 and endocarditis.