While increased PRDX6 is described in a number of neurodegenerative diseases and some cancers, only one disease, alcoholic steatitis, reports decreased PRDX6 protein content with a much lesser decrement in PRDX6 than that found for MFM horses (1.6-fold vs. 18-fold) (47). Here, PRDX6 is linked to neurodegenerative disease.