The genomic sequencing of S. renifolius has not yet been completed but we speculate that SrTrxo2, a shorter SrTrxo protein isoform, is a splicing variant in S. renifolius. In this regard, it has been reported that Trx splicing variant lacking exons 2 and 3 is substantially expressed in human cancer cells and that this alternatively spliced isoform was not expressed as a stable protein (32). The gene discussed is TXN; the disease is cancer.