CALB1 and early-onset autosomal dominant Alzheimer disease: It is well documented in the literature that calbindin-D28K has neuroprotective properties in the CNS (Yenari et al., 2001 ▸; Yuan et al., 2013 ▸; Sun et al., 2011 ▸), and it has recently been demonstrated that its depletion in an Alzheimer’s disease mouse model accelerates neuronal loss, apoptosis and mitochondrial dysfunction (Kook et al., 2014 ▸).