Recent work has hinted at a possible protective role of calbindin-D28K in inhibiting apoptosis and necrosis, and in slowing the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (Yuan et al., 2013 ▸; Yenari et al., 2001 ▸; Sun et al., 2011 ▸; Kook et al., 2014 ▸; Bellido et al., 2000 ▸). This evidence concerns the gene CALB1 and early-onset autosomal dominant Alzheimer disease.