In this study, we investigated the changes in the levels of cell adhesion molecules EpCAM, claudins, E-cadherin, tetraspanins, and PKCs at both protein and mRNA level after treating the colon cancer lines with PKC inhibitors (Bisindolylmaleimide I, Gö6976, and Rottlerin). This evidence concerns the gene EPCAM and colonic neoplasm.