In this study, we investigated the changes in the levels of cell adhesion molecules EpCAM, claudins, E-cadherin, tetraspanins, and PKCs at both protein and mRNA level after treating the colon cancer lines with PKC inhibitors (Bisindolylmaleimide I, Gö6976, and Rottlerin). Here, CDH1 is linked to malignant colon neoplasm.