Following recent links of MLLT1 knockdown and CRISPR knockout reducing AML tumorigenesis,5, 6 we profiled genes that were shown to be down‐ (MYC, myeloperoxidase (MPO), dendrin (DDN), cathepsin G (CTSG)) and up (CD86)‐regulated in MV4;11 AML cells after MLLT1 knockdown/out.5 Compound 92 changed gene expression of 3/5 genes, showing a reduction in MYC, DDN and an increase in CD86 compared to DMSO. The gene discussed is CTSG; the disease is acute myeloid leukemia.