HES1 and central nervous system cancer: The Notch signalling pathway functions as a vital regulator in embryo development via the regulation of intercellular signal communication by modifying cell proliferation and apoptosis42, 43, 44; both Hes‐1 and NICD have vital functions in Notch signalling pathway.44, 45 Gao et al found that the expression Notch signal‐related proteins Hes‐1 and NICD were decreased by silencing ZFAS1in glioma cell, suggesting ZFAS1 could regulate the expression of Hes‐1 and NICD to activate Notch signalling pathway (Figure 2E).