Although, the role of epigenetic changes in the etiology of endometriosis has not yet been determined, the present study together with mentioned studies (18, 23) supported the hypothesis that HOXA10 homeodomain transcription factor plays an important role in human endometrium, which is related to the success in the implantation, and also explains that HOXA10 is necessary for denovo endometrial development. The gene discussed is HOXA10; the disease is endometriosis.