Adjacent association of vacA, cagA, iceA, oipA and babA2 genotypes of H. pylori bacteria with secretion of interleukin-8 and cytotoxin, adhesion to gastric epithelial cells, occurrence of inflammatory effect, vacuolization, apoptosis procedure in gastric epithelial cells, peptic ulceration, increase acute neutrophilic infiltration, interleukin-10 secretion and inflammation, has been presented previously [48–50]. The gene discussed is S100A8; the disease is peptic ulcer disease.