The objective of the present study was to evaluate the effects of Enalapril, Losartan and Valsartan on the production of IL-2, IL-10, IL-6, TNF, IFN-γ, IL-17A, IL-17F and IL-22 cytokines in PBMCs of patients with rheumatoid arthritis and evaluate this modulation with disease activity. The gene discussed is IL22; the disease is rheumatoid arthritis.