PAPP-A < 0.4 was more frequent in patients who developed IUGR, preterm labor, and pregnancy induced hypertension (17.4% versus 1.2%, P<0.001; 13% versus 2%, p = 0.013; and 17.4% versus 4%, p = 0.015 respectively). The gene discussed is PAPPA; the disease is hypertension, pregnancy-induced.