ANXA5 and melanoma: In addition, CCCP/iron treatment for 24 h could barely induce the apoptosis of melanoma cells, as no obvious apoptotic features were detected, including DNA laddering (Supplementary information, Fig. S1q), annexin V (AnnV) single positive cells (Supplementary information, Fig. S1r), and nuclear fragmentation (Supplementary information, Fig. S1s).