Following treatment with certain apoptotic stimuli, activated caspase-3 cleaves GSDME to release its PFD for pore formation, consequently triggering secondary necrosis after apoptosis or pyroptosis.17,18 Despite the well-known anti-infection effect of pyroptosis in immune cells, whether the induction of pyroptosis could be adopted in cancer therapy remains unclear. Here, GSDME is linked to cancer.