PRDX2 and breast carcinoma: Likewise, when a range of breast cancer cell lines were analysed by western blotting (Fig. 1b), we noticed that PRDX1 and PRDX2 protein content is highly upregulated in breast cancer cells, as compared to primary human mammary epithelial cells HMEC and non-malignant, mammary tissue-derived MCF-10A cell line.