TNFSF12 and germinoma: The TWEAK signalling pathway is hypothesised to contribute to tumour proliferation and angiogenesis45 while the tec kinase signalling pathway plays a role in the activation of T- and B-cells.46,47 The RAR activation pathway plays an important role in developmental differentiation of cells.48 Various immune cell-related pathways had decreased methylation in germinomas/seminoma/dysgerminoma vs. YST.