KLF4 and colorectal cancer: Subsequently, we estimated the composition of immune cell types in same cohort of colorectal cancer patients using the computational inference approach CIBERSORT.9 This approach estimates the composition of immune cell types in complex tissues using gene expression profile as input.9 We observed a significant positive correlation between the KLF4 activity score and the estimated percentage of myeloid cell types: neutrophils, macrophages (M0, M1), mast cells (activated) and dendritic cells (activated) (Fig. 4b, Table S4).