A recent study highlighted a role of TGFβ signalling in the exclusion of T-cells (lymphoid lineage) from colorectal tumours in genetically engineered mouse models.17 TGFβ is a well known driver of tissue remodelling,18 but it is not clear how the exclusion of T-cells influences the abundance of myeloid cell types in colorectal cancers with increased tissue remodelling. The gene discussed is TGFB1; the disease is colorectal cancer.