They examined 337 unselected primary breast cancer cases for staining scores of p-AKT(Ser473), cyclin D1, P27, p-p70S6K, p-4EBP1 and p-ERK1/2, and cluster classification showed significant relationships with subgroups expressed by hormone receptor, HER2, grade and histological subtype, but not with prognosis. This evidence concerns the gene CCND1 and breast cancer.