We have previously shown that patients with ER+ tumours harbouring high p-AKT(Ser473), p-AKT(Thr308), p-mTOR or p-p70S6K expression who did not receive adjuvant tamoxifen also had a decreased risk of breast cancer recurrence.18 Other groups have analysed the prognostic significance of PIK3CA mutations or the expression of individual proteins. This evidence concerns the gene RPS6KB1 and breast carcinoma.