Importantly, while the most frequently mutated gene in module 8, XIRP2, is mutated in 27% of patients, and only 24 genes mutated in at least 10% of tumours, the majority of genes in the module are altered only in a small proportion of cases (Fig. 3d; similarly for module 18, Supplementary Fig. 2d). This evidence concerns the gene XIRP2 and neoplasm.