To determine the functional role of CLOCK and BMAL1 in tumor cells, two types of shRNAs (shCLOCK and shBMAL1 for short) were used to attenuate CLOCK and BMAL1 expression, and the CLOCK-expressing plasmid CLOCK-pcDNA3.1-HA and the BMAL1-expressing plasmid BMAL1-pcDNA3.1-HA (CLOCK+ and BMAL1+ for short) were used to increase their levels. This evidence concerns the gene CLOCK and neoplasm.