THBS1 and Familial prostate cancer: Consistently, mRNA expressions of EZH2 and TSP1 negatively correlate with each other in human prostate cancers, such as in Grasso_mCRPC (Spearman Correlation Rho = −0.55, P ≤ 1E-6) and in Beltran_NEPC (Rho = −0.53, P ≤ 8E-5) (Fig. 6c).