Additional supporting evidences came from a published dataset for prostate cancer GEM models46, where TSP1 is expressed at significantly lower level in prostate tumors from TRAMP mice (a classic NEPC GEM model) than in prostate tumors from NP mice (a classic prostate adenocarcinoma GEM model) (GSE53202, P = 1.36E-07). This evidence concerns the gene THBS1 and prostate cancer.