Interestingly, TSP1 expression is negatively correlated with that of EZH2 in the CCLE dataset for 1000 human cancer cell lines of many cancer types42 (Fig. 6e, Spearman Correlation Rho = −0.51, P ≤ 9.96E-57), which suggests that the EZH2/TSP1 axis exist broadly in human cancer cells. Here, THBS1 is linked to cancer.