GRM5 and depressive symptom measurement: These include NLGN1, KCND2, ELAVL4, NXPH1, GRM5, and GABRB1. We assessed the disease enrichment of the co-expressed genes using web-based tool WebGestalt44 and found that mental disorders, depression, bipolar disorder, and anxiety disorder were significantly enriched (FDR < 0.05, Table S3).