In addition, elevated DAPK1 activity is detected following brain injury due to ischemia [41,42], seizure [43,44], epilepsy [45], and Alzheimer’s disease (AD) [46,47] as well as in response to ceramide and glutamate toxicity [28,48], indicating a close relationship between DAPK1 and neuronal cell death [49]. Here, DAPK1 is linked to Alzheimer disease.