The chloroform fraction of Laurus nobilis, a DAPK1 non-selective inhibitor of plant origin, significantly improved the ischemic neuronal death through keeping DAPK1 in an inactivate form after oxygen and glucose deprivation in human SH-SY5Y neuroblastoma cell lines and organotypic hippocampal slice tissue. This evidence concerns the gene DAPK1 and neuroblastoma.