The role of DAPK activity in the histone deacetylase inhibitor (LBH589)-induced apoptosis in HCT116 wildtype colon cancer cells was clarified by using a selective DAPK1 inhibitor, 2-phenyl-4-(pyridin-3-ylmethylidene)-4,5-dihydro-1,3-oxazol-5-one, known as TC-DAPK6, for inhibition of DAPK1 catalytic activity [26,103]. The gene discussed is DAPK1; the disease is colonic neoplasm.