Plasma ACTH also did not change following LPS challenge in both SLE and control mice (3.0 ± 0.5 vs. 3.7 ± 0.5 and 3.0 ± 0.3 vs. 4.3 ± 0.6 ng/mL, p = 0.393, respectively). Here, POMC is linked to systemic lupus erythematosus.