Interestingly, resistance to both endogenous and exogenous glucocorticoids is primarily induced by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) that plays a role in animal models of autoimmune disease, such as multiple sclerosis, Guillain-Barre syndrome, and SLE [48,49,50]. The gene discussed is MIF; the disease is systemic lupus erythematosus.