Lastly, LPS-challenged SLE mice had increased brain TNF-α compared to LPS-challenged control mice (6.6 × 106 ± 3.9 × 106 vs. 2.6 × 105 ± 1.1 × 105 intensity units, p = 0.045 for 26 kDa; 5.1 × 106 ± 2.8 × 106 vs. 1.1 × 105 ± 2.4 × 104 intensity units, p = 0.027 for 51 kDa). This evidence concerns the gene TNF and systemic lupus erythematosus.