Zhang et al. reported a liver-enriched lncRNA named liver fibrosis-associated lncRNA1 (lnc-LFAR1); mechanistic studies revealed that lnc-LFAR1 promotes liver fibrosis by directly regulating the binding of Smad2/3 to TGFβR1 that develops a TGF-β1/Smad2/3/lnc-LFAR1 feedback loop [66]. This evidence concerns the gene TGFB1 and Hepatic fibrosis.