SMAD3 and renal fibrosis: Furthermore, another novel Smad3-dependent lncRNA Erbb4-IR (np 5318) has been demonstrated to promote renal fibrosis in both UUO-induced and diabetic nephropathy mouse models through suppressing Smad7 and miR-29b, respectively; targeting renal Erbb4-IR effectively inhibited the progression of kidney fibrosis in mice [59,60].