TGF-β-mediated methylation of MEG3 promoter causes a decrease in the expression of this antifibrotic lncRNA, which accelerates liver fibrosis [69]; meanwhile, MEG3 could induce lncRNA p53-mediated apoptosis via modulating Bax/Bcl-2 and cytoplasmic cytochrome expression [92]. The gene discussed is MEG3; the disease is Hepatic fibrosis.