RECK and neoplasm: RECK was initially isolated as a transformation suppressor gene against the v-K-ras oncogene (Takahashi et al., 1998); subsequent studies implicated RECK in suppression of tumor growth, angiogenesis, invasion, metastasis and recurrence (Hill et al., 2011; Noda and Takahashi, 2007; Oh et al., 2001; Yoshida et al., 2012).