Our previous microarray assay and the following studies showed that E2F2 expression is significantly higher in RA synovial tissue than in osteoarthritis (OA), and that E2F2 is associated with the pathological progression of RA and can exacerbate inflammatory phenotypes in RASFs, such as proliferation, invasion, and cytokine production in vitro [7]. The gene discussed is E2F2; the disease is osteoarthritis.