AD, Alzheimer’s disease; AsymAD, asymptomatic Alzheimer’s disease; MCI, mild cognitive impairment; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease amyloid-β plaque load score; Braak, Braak stage for tau tangle burden; PMI, post-mortem interval; ApoE, apolipoprotein E isoform genotype. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.