To ascertain the mechanism of action of HOXC-AS3/YBX1-driven oncogenesis of GC and to determine the gene expression changes downstream of HOXC-AS3, we evaluated the global effects of HOXC-AS3 knockdown compared with those of YBX1 knockdown using RNA transcriptome sequencing (Fig. 6a, Additional file 5: Table S4 and Additional file 6: Table S5). Here, HOXC-AS3 is linked to gastric cancer.