Finally, Gfi1 also decreases the pro-apoptotic effects of p53 in lymphoblastic leukemia by binding to the regulatory regions of pro-apoptotic genes, such as BAX, Pmaip1 (NOXA), and Bbc3 (PUMA); blocking p53 binding; and decreasing methylation of p53-K372 [12]. Here, PMAIP1 is linked to acute lymphoblastic leukemia.