In our previous work, we determined that RHBDD1 was highly expressed in colorectal cancer tissues but weakly expressed in adjacent normal tissues, and could activate the EGFR/Raf/MEK/ERK signaling pathway through the cleavage and secretion of TGFα as well as up-regulation of EGFR expression [20, 21]. This evidence concerns the gene RHBDD1 and colorectal cancer.