Although NKp30 has been shown to bind PfEMP1 [18], the role of PfEMP1 in NK cell activation remains controversial because NK cells can still be activated by parasite that does not express surface PfEMP1 [19] and blocking of NKp30, NKp44 or NKp46 with antibodies does not affect NK cell control of parasitemia in vitro [10]. This evidence concerns the gene NCR3 and parasitic infectious disease.