In the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) study, albuminuria, hypoalbuminemia, increased serum creatinine, and decreased hemoglobin were the risk factors associated with ESRD in patients with type 2 DM and nephropathy [14]. The gene discussed is AGT; the disease is Hypoalbuminemia.