INS and cancer: KEGG pathway enrichment analysis of significantly dysregulated circRNAs showed significant enrichments in cell-growth, immune and cancer-associated pathways, such as the mTOR signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling patheway, Jak-STAT signaling pathway, Insulin signaling pathway and the ErbB signaling pathway (Fig 3B).