CASP3 and early-onset autosomal dominant Alzheimer disease: These data corroborated the findings of Fang et al. [98], who observed lower Bax and caspase-3 expressions as well as higher expression of the anti-apoptotic protein after MVIIA injection in a cell-based model of Alzheimer's disease conducted in mice in vitro and the same at the cisplatin model in vitro, that Leo et al. [59] showed prevented caspase-3 activation.