Since, upregulated p38 and ERK are associated downregulated filaggrin and involucrin expression [27], p38 MAPK signaling pathway positively regulates the production of proinflammatory cytokines [28], and JNK is negatively associated with differentiation of epidermal keratinocytes [29], therefore the data obtained suggests possible molecular pathway responsible for AD symptoms manifestation. This evidence concerns the gene MAPK8 and Alzheimer disease.