In this study, we demonstrated that EMF downregulates the expression of Fas, FasL, percentage of p-ERK, p-JNK and p-p38 MAPK positive cells, and the secretion of IL-1β, IL-4, IL-10, IL-12p70, IL-13, IL-17A, IL-31 and TNFα in the AD keratinocytes, which should have a positive impact on the weakening of the symptoms. The gene discussed is MAPK8; the disease is Alzheimer disease.