EGF and central nervous system cancer: In this work, we did not take into account many microenvironmental factors such as endogenous immune dynamics [147], signaling networks [148, 149], angiogenesis [148, 150], biophysical interaction between a glioma and blood vessels [148], ECM remodeling for therapy [149, 151–153], or growth factors [154, 155] such as fibroblast growth factors (FGF) [156] and epidermal growth factors (EGF) [49, 157, 158] transforming growth factor-β (TGF-β) [49, 159], CSF-1 [49, 160], that may play key roles in progress, aggression, invasion of gliomas and development of anti-cancer strategies [161].