Conversely, under HF diet CrM supplementation was not able to improve muscle performance measured as maximal carrying load, total isotonic force and work under HF diet, without the expected muscle hypertrophic effect and the expected change on muscle fiber type (Fig 3) due to inhibition of protein expression of IGF1-IRS1-PI3K-AKT-mTOR pathway. The gene discussed is IRS1; the disease is hydrops fetalis.