Colorectal cancer cells immunopositive for FZD10, however, showed significantly less nuclear accumulation of β-catenin than FZD10-immunonegative cells, and there was a strong inverse correlation between nuclear immunostaining scores for β-catenin expression and expression patterns of FZD10, suggesting that FZD10 has a distinct role in canonical Wnt signal transduction [35]. The gene discussed is FZD10; the disease is colorectal cancer.