Of these 15 genes (STXBP6, MGAT3, BCL6B, FZD10, HSPB6, PF4V1, KLF4, PTGFR4, PDLIM2, LAMA4, ASPRV1, GATA2, HOXA2, LHX6, and KLF2), 11 had not previously been reported in lung cancer (except GATA2, HOXA2, LHX6, and KLF2; Fig 1). This evidence concerns the gene KLF2 and lung cancer.