The expression of STXBP6, BCL6B, FZD10, and HSPB6 mRNAs was significantly downregulated in patients younger than 45 years (Fig 6G, p = 0.029, p = 0.040, p = 0.043, p = 0.034, respectively), while no correlation was observed between the expression of the 4 candidate genes and other clinicopathologic features such as patient sex, smoking history, disease stage, or lymph node metastasis. Here, STXBP6 is linked to metastatic malignant neoplasm in the lymph nodes.