STXBP6 mRNA expression was downregulated in 66.67% of tumor tissues, BCL6B was downregulated in 69.23%, FZD10 was downregulated in 71.79%, and HSPB6 was downregulated in 74.36% (Fig 5A and S9 Table, p <0.001). The gene discussed is HSPB6; the disease is neoplasm.