Pathway analysis showed these genes were involved in many pathways, such as metabolic pathways, pathways in cancer, cAMP signaling pathway, and pathways involved in neuroactive ligand-receptor interaction, melanogenesis, HTLV-I infection, glutamatergic synapse, alcoholism, longevity, GABAergic synapse, PI3K-Akt signaling, calcium signaling, and estrogen signaling. The gene discussed is AKT1; the disease is alcohol dependence.