STXBP6 and neoplasm: STXBP6 protein expression was downregulated in 91.43% of tumor tissues, BCL6B was downregulated in 88.57%, FZD10 was downregulated in 88.57%, and HSPB6 was downregulated in 91.43% (Fig 5B and 5C and S10 Table, p <0.001, the original blots of western blots is shown in the S1–S8 Figs).