Despite the evidence that regulatory T cells inhibit anti-tumor responses in the tumor microenvironment and that strategies targeting their depletion in mouse models provide anti-tumor benefit [65, 70], it is interesting to note that in the TCGA breast cancer data set high expression of FOXP3 does not predict poorer outcomes and in fact may correspond with better overall survival (Fig. 8f). The gene discussed is FOXP3; the disease is neoplasm.