Synergism from this combination may be expected as the ex vivo grown and expanded tumor-reactive TIL are often PD-1 positive [63] and prevention of the interaction between PD-1 on T cells and PDL-1 on tumor cells by anti-PD-1 therapy around the time of TIL infusion, may render these TIL more tumoricidal. Here, CD274 is linked to neoplasm.