The pooled incidences of all-grade and high-grade pneumonitis in patients treated with PD-1/PD-L1 inhibitors were 3.2% and 1.1%, respectively [24], while our data revealed that the incidence of serious nivolumab-related pneumonitis was 0.9%, and the incidence of FAEs caused by pneumonitis was 0.2%. The gene discussed is CD274; the disease is pneumonitis.