High infiltration of Foxp3+ Tregs was significantly associated with shorter survival in the majority of solid tumors studied, such as renal, melanomas, and breast cancers; whereas Foxp3+ Tregs were associated with improved survival in colorectal, head and neck, and esophageal cancers, suggesting the organ local microenvironment may significantly influence the function of Foxp3+ Tregs. The gene discussed is FOXP3; the disease is esophageal cancer.