PRDM1 is known to repress BCL6 and PAX5 [63–66], but epigenetic mechanisms may play a major role in B cell transcription factor silencing during plasma cell differentiation as underlined by the bivalent domain of PAX5, including H3K4me3 and H3K27me3 marks, identified in MM cells (Additional file 1: Figure S13). This evidence concerns the gene PRDM1 and Miyoshi myopathy.