Using Affymetrix microarrays, we analyzed the expression of PRC2 core genes EZH2, SUZ12, and EED in normal bone marrow plasma cells (BMPCs, n = 5), primary myeloma cells from patients (MMCs, n = 206), and human myeloma cell lines (HMCLs, n = 26). The gene discussed is EZH2; the disease is plasma cell myeloma.