Furthermore, although Wagner, et al. [11] reported TSC1 loss in PEComa, genomic sequencing of TSC1 and TSC2 was not performed in these cases, as they predate the widespread use of next-generation sequencing, and the histologic subtype (e.g. angiomyolipoma) was not specified. This evidence concerns the gene TSC1 and angiomyolipoma.