Several mechanisms have been suggested for the pathogenesis of hypertension, including increased activity of the sympathetic nervous system, overactivation of the renin-angiotensin-aldosterone system, dysfunction of the vascular endothelium, impaired platelet function, thrombogenesis, vascular smooth muscle and cardiac hypertrophy, and altered angiogenesis [14, 39]. This evidence concerns the gene REN and cardiac hypertrophy.