The majority of patients with IgG4-RD do not in fact show increased eosinophils counts or serum IgE levels at the time of diagnosis, and most of the data regarding the value of IgG4 levels in predicting disease relapse failed to demonstrate any definitive associations in different study cohorts [7, 8]. The gene discussed is IGHE; the disease is immunoglobulin G4-related sclerosing disease.