Inhibition of NF-κB and Jun N-terminal kinase (JNK) activation significantly decreases production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) and MMPs (MMP-1 and MMP-3) in RA-FLSs [60]. This evidence concerns the gene CXCL8 and rheumatoid arthritis.