The expression of 71.4% (20 out of 28) of these BHLHE40-dependent genes (as shown in Fig. 4a) was found to be positively correlated with BHLHE40 expression, with statistical significance (p <  0.05) in at least one of the four major subtypes of breast tumors (Table 1). This evidence concerns the gene BHLHE40 and breast neoplasm.